Deaths per year from adverse drug interactions in the US
40%
Of adults 65+ take 5 or more medications daily
500+
Medications, supplements, and peptides in the StackRx database
Pillar 1 — Strategy
Your meds are fighting each other. We fix that.
Every dose, timed to the hour — with the clinical rationale behind each decision. StackRx maps absorption profiles, drug-drug interactions, food requirements, and your lab values across your entire stack: Rx, supplements, peptides, OTC, and research compounds.
💊 Prescription (Rx)🌿 Supplements⚗️ Peptides🧪 GLP-1s💊 OTC🔬 Research Compounds
Empty stomach. Calcium, iron, and antacids block absorption at the intestinal transporter level — must be separated by 4 hours minimum. TSH trending toward optimal range; maintain current timing discipline.
8:00 AM
Lisinopril 10mg + Metformin 500mg
Safe to combine. Take with breakfast to reduce metformin GI effects. eGFR 52 (CKD Stage 3a) — metformin dose reviewed, renally-cleared medications adjusted. NSAIDs flagged as contraindicated in this strategy.
12:00 PM
Vitamin D3 2000IU + Calcium 600mg
D3 enhances calcium absorption — take together. Separated 6 hours from levothyroxine to prevent competition. Vitamin D deficient at last draw (18 ng/mL); dosing reflects active repletion protocol.
9:00 PM
Atorvastatin 20mg
LDL 118 — timing aligned with peak hepatic cholesterol synthesis (9PM–midnight) for maximum statin efficacy. Evening dosing improves LDL reduction by 15% vs. morning equivalent. Not a reminder. A reason.
Pillar 2 — Lab Proof
Upload your labs. See the proof. Tiny ticks in the right direction.
Quarterly labs show whether the strategy is actually working. A1C dropping 0.2. eGFR stabilizing. LDL trending down. The motivating force behind every discipline decision — and the early warning system if something's going the wrong direction.
Lab Trend Tracker — 3-Quarter View
Uploaded via PDF · Parsed automatically · 22 values tracked
📈 Improving⚠️ Watch
A1C
7.2 → 6.9 → 6.7
↓ 0.5
LDL
132 → 124 → 118
↓ 14
eGFR
49 → 51 → 52
↑ 3 ✓
TSH
3.8 → 3.2 → 2.7
↓ 1.1
ALT
28 → 31 → 33
↑ 18%
ALT trending up 18% over 3 quarters. Three new compounds added since January. StackRx has flagged this for Over-Stacking review — see below.
The biohacker community didn't have a word for it. Now it does: Over-Stacking.
Piling on compounds until your labs show the damage. A cholesterol spike from over-supplementation. Liver enzyme creep from aggressive stacking. Kidney strain from nephrotoxic compounds taken simultaneously. StackRx catches Over-Stacking before it becomes a crisis — trending labs + compound accumulation = early warning.
🔴
Over-Stacking Detected
Your liver enzymes (ALT) have trended up 18% over the last two quarters. You've added 3 new compounds since January. Your stack may be working against itself.
NAD+ (NMN) 500mg
Added Feb
Alpha-Lipoic Acid 600mg
Added Mar
Berberine 500mg
Added Apr
Trending labs + compound accumulation = early warning
StackRx connects the dots between what you added and what your labs show. Not an alarm when you're in crisis — a flag when you're still in control.
Works for kidneys too
CKD patients face the same risk from the other direction. Nephrotoxic combinations — NSAIDs, certain supplements, contrast agents — compound quietly until eGFR drops. Over-Stacking alerts surface this before labs decline.
Pillar 3 — Fewer Meds
The goal isn't more meds managed better. It's fewer meds, period.
The endgame isn't optimizing 12 medications perfectly. It's getting to 8. Then 6. Daily to every-other-day. 40mg to 20mg. Lab evidence earned it. The app that helps you stop taking things is more trustworthy than the one that helps you take them.
Before
9 substances · daily
Metformin 1000mg twice daily
Atorvastatin 40mg
Lisinopril 10mg
Levothyroxine 75mcg
Vitamin D3 2000IU
Calcium 600mg
Berberine 500mg
Fish Oil 2g
Magnesium Glycinate 400mg
A1C: 7.2 · LDL: 132 · eGFR: 49
18 Months Later
6 substances · optimized
Metformin 500mg once daily↓ dose — A1C 6.7
Atorvastatin 20mg↓ dose — LDL 96
Lisinopril 10mg
Levothyroxine 75mcg
Vitamin D3 — levels normalized, discontinued
Calcium 600mg
Berberine — Over-Stacking flag, removed
Fish Oil — LDL managed by statin, discontinued
Magnesium Glycinate 400mg
A1C: 6.7 · LDL: 96 · eGFR: 54 · Lab-confirmed.
Every other app wants you to take more. StackRx gives you the strategy — and the lab evidence — to take less.
Why this exists
Why we built it
Three lines that lay out what StackRx is responsible for — and what it intentionally stays out of.
Built For
Complex medication situations require more than reminders.
Whether you're managing a parent's regimen across multiple specialists, tracking your own aggressive biohacker stack, or navigating CKD with a kidney that doesn't forgive mistakes — StackRx is the analysis layer clinical care currently lacks.
Caregiver👵
Managing a loved one's complex regimen
Your parent sees a PCP, a cardiologist, an endocrinologist, and a telehealth provider. None of them have the full prescription list. You didn't either — until StackRx. One unified strategy you can share with every provider and print for the bedside.
CKD / Kidney🫘
Kidney community — eGFR matters more than you think
CKD patients face the highest stakes for getting this right. Nephrotoxic combinations, renally-cleared drugs at the wrong dose, NSAIDs that silently erode function. StackRx tracks your eGFR trajectory, flags nephrotoxic compounds in your stack, and builds your entire strategy around your actual kidney function — not population averages. Dialysis prevention is the goal.
Biohacker⚗️
Biohackers stacking with confidence
BPC-157. Semaglutide. NAD+ precursors. Peptides nobody warned you about. StackRx is the safety net between your stack and the interactions no single provider oversees. Confidence-tiered dosing. Over-Stacking alerts. The feedback loop the community has been missing.
Polypharmacy💊
Anyone on 5+ substances daily
Most Americans don't realize they qualify. Rx from two providers, a daily supplement stack, and a few OTC items you've never mentioned to a doctor. StackRx sees the complete picture — and flags the conflicts your pharmacy software missed.
Built by
Built by a caregiver
The product comes out of a caregiver's lived context and a Systems Architect's instinct for surfacing what authoritative sources already say.
Research Compounds
Peptides and research compounds — with confidence-tiered dosing.
The dosing information the biohacker community has been asking for. Every peptide, GLP-1, and performance compound in the database — sourced, tiered, and transparent.
Confidence-Tiered Dosing
Every compound rated by evidence quality. No guessing about sources.
⚗️ For research purposes only
FDA-Approved
FDA-approved — Full clinical evidence
Approved pharmacokinetics, established interaction profiles, clinical trial dosing data.
Clinical Trial Data
Clinical trial data — Limited human evidence
Phase I/II data or peer-reviewed human studies. Mechanism understood, full safety profile not yet established.
Community-Reported
Community-reported — Use with caution
Anecdotal, animal data, or forum-sourced. Displayed for completeness. Limited clinical evidence available.
Semaglutide (GLP-1)TirzepatideBPC-157TB-500NAD+ / NMNSermorelinMK-677Ipamorelin⚗️ 500+ total
Why StackRx
Other apps help you take pills. We help you prove the stack is working — and shrink it.
If you landed here from a pill tracker, a diabetes stacking site, or a kidney forum — StackRx is in a different category. Not a logger. A trajectory platform with a goal of less.
Full timing optimization for up to 4 medications at no cost. The Pro tier unlocks lab trend tracking, Over-Stacking alerts, and the full trajectory engine.
⚕️
For informational purposes only. Not a substitute for medical advice.
⚗️
Research compounds labeled for research purposes only.
Strategy. Lab proof. Fewer meds.
StackRx is the clinical trajectory platform your medication regimen has been missing. Not a reminder app. Not an interaction checker. A strategy engine with a real goal: less.